Most Rejuran comparisons turn the range into a four-row treatment-area chart. That may help a patient remember the names, but it leaves the clinic with the harder question: how many separate services, stock units and handling routines does the business actually need?
The difference becomes clearer when the boxes are treated as inventory rather than colours. The standard black-box Rejuran comes as two 2 cc syringes. Rejuran I and S each come as a single 1 cc syringe. Rejuran HB adds sodium hyaluronate and lidocaine to its PN formulation, arrives as a single 1 mL syringe and, unlike the other three products, is listed for refrigerated storage. The range is therefore not a simple ladder from light to strong. It is a four-role clinic system.
Quick answer
A clinic does not automatically need all four
Use the standard Rejuran product as the broad core of the line; consider Rejuran I when the menu needs a more precise product role for thinner areas; consider Rejuran S when the clinic actively operates a focused wrinkles-and-scars service; and consider Rejuran HB when hydration, added lidocaine and a distinct comfort conversation justify a refrigerated SKU.
The useful question is not “Which Rejuran is best?” It is “Which product roles can this clinic explain, deliver and reorder consistently?”
This is a product-selection and stocking guide for aesthetic professionals. It does not provide injection depths, doses, protocols or individual treatment recommendations.
The core four
One PN family, four different clinic jobs
PharmaResearch lists four core Rejuran medical-device products: REJURAN, REJURAN I, REJURAN S and REJURAN HB Plus. Their shared family identity matters, but it should not erase the documented differences in product role, pack format, composition and storage.
| Product | Manufacturer positioning | Published composition | Pack unit | Published storage | Clinic-menu translation |
|---|---|---|---|---|---|
| REJURAN / Healer | Standard facial-wrinkle product; described by the manufacturer as the broad full-face member of the line | PN | 2 cc per syringe; 2 syringes per pack | 1–30°C, shaded storage | Core PN service |
| REJURAN I | Face—especially eye and perioral areas—plus neck, décolleté and hands | PN | 1 cc × 1 syringe | 1–30°C, shaded storage | Precision-area extension |
| REJURAN S | Facial wrinkles; the manufacturer’s lineup statement also positions S around wrinkles and scars | PN | 1 cc × 1 syringe | 1–30°C, shaded storage | Focused wrinkles-and-scars service |
| REJURAN HB Plus | PN product with added hydration and pain-relief positioning | Sodium polynucleotide, sodium hyaluronate, lidocaine hydrochloride | 1 mL × 1 syringe | 2–8°C, protect from light | Comfort-and-hydration extension |
Variant architecture
The range is not a stronger-versus-weaker ladder
Healer, I, S and HB are often described with shorthand labels because shorthand is easy to remember. The risk is that the shorthand turns into a false ranking: Healer as the “basic” option, HB as the “premium” option, I as the “weak” option and S as the “strong” option.
That is not what the published structure shows. I and S share a 1 cc format and PN composition, yet the manufacturer gives them different product roles. HB changes the formula and storage requirement rather than simply moving “above” Healer. The standard product has the largest pack unit, but pack size does not make it universally preferable.
For a clinic, this matters because selling by hierarchy creates the wrong conversation. A higher invoice line can begin to sound like a better treatment, while a smaller syringe can sound less valuable. A role-based menu avoids both mistakes: each SKU stays only when it solves a service problem that another SKU does not solve as clearly.
The anchor product
Healer gives the range a centre—but not the whole map
Core role
Standard REJURAN / Healer
The black-box product is the broadest entry point and the only member of the core four published as two 2 cc syringes per pack. That makes it the natural anchor for a clinic that wants one recognizable PN service before creating specialist extensions.
Alternative role
REJURAN HB
HB should not be sold as Healer with a higher status. Its additions—sodium hyaluronate and lidocaine—create a different hydration and comfort proposition, while refrigeration creates a different operational requirement.
Starting with Healer does not mean every consultation belongs to Healer. It means the clinic begins with the product that carries the broadest brand recognition and then earns each additional SKU by identifying a repeatable client question.
A deceptively similar pair
I and S prove that the same 1 mL format can support two different services
Precision role
REJURAN I
The official product page does more than label it an eye product. It names the eye and perioral areas within a wider list that also includes the neck, décolleté and hands. The useful menu idea is therefore precision and thinner-area work—not an eye-only slogan.
Focused role
REJURAN S
PharmaResearch’s lineup statement places S around wrinkles and scars. That gives it a focused service identity, but not permission to promise that every scar type or textural concern is suitable for the same product plan.
A clinic that routinely receives thin-area questions may find a clear place for I without carrying S. A practice with a genuinely structured scar service may find the reverse. Carrying both is sensible only when the consultation paths, staff training and reorder patterns remain distinct.
The operational outlier
HB changes the consultation—and the back-room workflow
HB is the only core-four product whose official page lists sodium hyaluronate and lidocaine hydrochloride alongside sodium polynucleotide. PharmaResearch’s 2024 product statement reports that HB Plus reduced procedure pain by 53% compared with the original Rejuran Healer and positions the HA component around hydration. That is a manufacturer-reported comparison, not a universal promise for every patient.
The team can explain HB as a different product experience: PN remains part of the formula, while HA and lidocaine create a separate hydration-and-comfort story. That is more meaningful than saying “red box versus black box.”
The official HB page specifies 2–8°C refrigerated, light-protected storage. The standard product, I and S list 1–30°C shaded storage. Before ordering HB, the clinic therefore needs a reliable receiving, refrigeration and stock-rotation routine.
This is exactly where a buyer guide can add value beyond a patient-facing comparison. The right product can still be the wrong SKU for a clinic that cannot support its storage and turnover requirements consistently.
Clinic menu builder
Three stocking models are more useful than one “complete range”
Model 01
Core PN menu
Start with standard Rejuran.
- One recognizable service story
- Largest published pack unit
- Lowest training complexity within the range
- No refrigerated HB workflow
Model 02
Core + one extension
Add I or HB according to repeat demand.
- I for a distinct precision-area service
- HB for a hydration-and-comfort proposition
- Two clear consultation scripts
- Controlled inventory expansion
Model 03
Specialist four-role menu
Carry all four only when each earns a role.
- General PN service
- Precision-area service
- Focused wrinkles-and-scars service
- Comfort-and-hydration service
The model should follow the clinic’s actual appointment mix, not the visual appeal of a complete shelf. A fourth SKU adds more than purchase cost: it adds training, expiry exposure, storage checks, stock counts and another explanation the whole team must deliver consistently.
Consultation talking points
Sell the role first, then name the product
A four-name introduction makes the client do the sorting. A role-first explanation keeps the professional recommendation at the centre of the conversation.
“These products share the Rejuran PN platform, but they do not perform the same menu job.”
“We are not choosing between a basic and premium version. We are matching the product role to the consultation goal.”
“The product name comes after the service decision, not before it.”
This language also protects margin without turning the consultation into a price comparison. The team can explain why two products sit at different commercial positions without placing one above the other as a universal winner.
Naming map
Healer, Black, HB and HB Plus are not four extra products
PharmaResearch’s product page uses REJURAN. “Healer” is common search and clinic language, while “black” is packaging shorthand. Cytollia’s black-box listing is the standard core product in this guide.
The letters identify two separate 1 cc PN products. They are not smaller versions of the same SKU and should remain separate in quotes and stock records.
PharmaResearch uses HB Plus on its English product page; Cytollia’s current catalogue uses HB. The exact box, market documentation and supplied item should be checked at ordering.
Tone-Up Booster, Skinbooster 3+3 and Trueskin Essence are not automatically additional members of the same core-four comparison. They need their own product classification and buying question.
What the evidence adds
Published PN research supports the category—not every sales sentence
Clinical literature provides useful context for polynucleotide use in aesthetic medicine. A randomized split-face trial compared a PN product with non-crosslinked HA in periocular rejuvenation, while a recent systematic review summarized studies across wrinkles, skin quality and scars. A 2024 case-series paper also examined Rejuran-based treatment across several facial scar types.
Those studies do not turn Healer, I, S and HB into interchangeable products, and they do not validate every clinic marketing claim. This guide therefore uses manufacturer product pages for composition, pack and storage facts; academic literature is used to explain why PN has a legitimate evidence base, not to invent product-specific superiority.
The decision
The best Rejuran range is the one your clinic can keep distinct
A clinic with one broad PN service may need only the standard product. A practice that regularly separates precision-area work or a hydration-and-comfort pathway may justify I or HB. S belongs when wrinkles-and-scars consultations are a real, repeatable part of the business rather than an occasional request.
The commercial advantage is not owning four colours. It is making each SKU easy to train, easy to explain and easy to reorder. When two products cannot hold separate roles in the consultation, they will eventually compete for the same appointment—and one will become slow stock.
Frequently asked questions
Questions clinics ask about the Rejuran range
What is the main difference between Rejuran Healer, I, S and HB?
The standard product provides the broad core role. I is positioned for more precise and thinner-area use, S is positioned around wrinkles and scars, and HB adds sodium hyaluronate and lidocaine while requiring refrigerated storage.
Is Rejuran HB stronger than Healer?
That is not a useful ranking. HB has a different composition and product experience; the standard product has a different pack size and broad core role. The clinic should compare the job each product needs to perform.
Do Rejuran I and S both come as 1 mL syringes?
Yes. PharmaResearch lists each as one 1 cc syringe per pack. Their shared format does not make them the same product role.
Does Rejuran HB need refrigeration?
The manufacturer’s English product page specifies refrigeration at 2–8°C and protection from light. Clinics should also confirm current transport and local handling requirements before ordering.
Is the black box the same as Rejuran Healer?
The manufacturer’s product page calls the standard product REJURAN, while “Healer” and “black box” are widely used market terms. Quotes and deliveries should still be checked against the exact supplied product.
Does a clinic need to stock all four Rejuran products?
No. Each additional SKU should correspond to a distinct and repeatable service role, supported by staff training, storage capacity and sufficient appointment demand.
Is Rejuran PN or PDRN?
PharmaResearch’s official product pages describe the core four using PN or sodium polynucleotide terminology. Related PDRN language appears widely in the market, but this guide follows the manufacturer’s product wording.
Which Rejuran product is best?
There is no universal winner. Product selection depends on the documented product role, the clinic’s service design and an appropriately qualified professional assessment.
Current Cytollia catalogue
Compare the four core Rejuran products
Review the exact product listing, current availability and live commercial information before ordering.
Core PN roleREJURAN Healer BlackView product details →Precision-area roleREJURAN IView product details →Wrinkles-and-scars roleREJURAN SView product details →Comfort-and-hydration roleREJURAN HBView product details →
Current product information and availability are maintained on the linked product pages. No fixed price is embedded in this guide.
Sources and editorial notes
- PharmaResearch — REJURAN product information
- PharmaResearch — REJURAN I product information
- PharmaResearch — REJURAN S product information
- PharmaResearch — REJURAN HB Plus product information
- PharmaResearch — 2024 HB Plus product-line statement
- Randomized split-face trial of PN and HA in periocular rejuvenation
- Systematic review of polynucleotides in aesthetic medicine
- Polynucleotide-based treatments for various facial scars
Last verified: August 3, 2026. Product names, pack units, composition and storage statements were checked against the linked manufacturer pages. Market availability and documentation can change.
Commercial disclosure: Cytollia sells the Rejuran products linked in this guide. The editorial comparison is organized around documented product attributes and clinic purchasing logic; it does not determine clinical superiority or replace professional assessment.