AestheFill® 200mg — PDLLA Collagen Biostimulator Lyophilized Powder
- PDLLA (poly-D,L-lactic acid) collagen biostimulator — gradual neocollagenesis
- 200mg lyophilized powder per vial, reconstituted with ~8mL sterile water
- Results develop progressively over weeks to months, lasting up to ~2 years
- Faster reconstitution and lower water requirement than conventional PLLA
- Typical protocol: ~3 sessions, 4–6 weeks apart, 1–2 vials per session
- KFDA-approved — Made in South Korea by REGEN Biotech
| 1 – 2 boxes | $310.00 / vial |
| 3 – 9 boxes | $294.50 / vial |
| 10 – 19 boxes | $279.00 / vial |
| 20 – 29 boxes | $269.70 / vial |
| 30+ boxes | Contact for quote |
What Is AestheFill® 200mg — PDLLA Collagen Biostimulator Lyophilized Powder?
AestheFill® 200mg is a poly-D,L-lactic acid (PDLLA) collagen biostimulator from REGEN Biotech (South Korea), supplied as a lyophilized powder of microsphere pellets for reconstitution with sterile water before use.
AestheFill® is a PDLLA (poly-D,L-lactic acid) collagen biostimulator that works differently from hyaluronic acid fillers. Rather than adding gel volume directly, AestheFill's PDLLA microspheres prompt the skin to generate new collagen gradually over weeks to months, delivering natural-looking, progressive volume restoration. PDLLA is an amorphous form of polylactic acid that reconstitutes faster and needs less water than conventional PLLA. Each vial contains 200mg of PDLLA microspheres in a CMC carrier, reconstituted with approximately 8mL of sterile water for injection. The product is fully biodegradable and is cleared by the body after completing its collagen-stimulating action.
Specifications
| Product name | AestheFill® 200mg |
|---|---|
| Brand | AestheFill (REGEN Biotech) |
| Type | PDLLA collagen biostimulator |
| Active ingredient | Poly-D,L-lactic acid (PDLLA) microspheres |
| Carrier | Sodium carboxymethylcellulose (CMC) |
| Strength | 200 mg per vial |
| Presentation | 200 mg × 1 vial, lyophilized powder |
| Preparation | Reconstitute with ~8 mL sterile water for injection (SWFI) |
| Protocol | ~3 sessions, 4–6 weeks apart, 1–2 vials per session |
| Injection depth | Deep dermis / superficial subcutaneous |
| Mechanism | Gradual collagen biostimulation (neocollagenesis) |
| Duration | Up to approximately 2 years |
| Treatment areas | Facial volume restoration, nasolabial folds, marionette lines, cheek augmentation, chin, jawline contouring |
| Origin | South Korea (REGEN Biotech) |
| Certification | KFDA |
| Storage | Store per product labeling; do not freeze reconstituted suspension |
| Shelf life | 24 months from manufacture date |
Key Benefits
- Gradual, natural-looking collagen stimulation produces subtle, progressive volume restoration without an artificial 'overfilled' appearance
- PDLLA amorphous microsphere structure enables faster reconstitution times and lower water requirements than conventional crystalline PLLA formulations
- Fully biodegradable — PDLLA microspheres are broken down and naturally cleared by the body after stimulating new collagen formation
- Versatile treatment protocol with customizable dosing (1–2 vials per session) allows tailored correction for each patient's needs
- Long-lasting results of up to approximately 2 years provide extended intervals between maintenance treatments
Suggested Treatment Protocol
AestheFill® 200mg is supplied as a lyophilized powder that must be reconstituted before use. Add approximately 8 mL of sterile water for injection (SWFI) to the vial and gently swirl until an even suspension forms. Official guidance recommends using sterile water rather than saline. The reconstituted suspension is injected into the deep dermis or superficial subcutaneous plane. A typical treatment course consists of approximately 3 sessions spaced 4–6 weeks apart, using 1–2 vials per session depending on the treatment area and goals. Post-injection massage may be recommended by the practitioner to ensure even distribution. Results build gradually over weeks to months as new collagen forms, with final results best assessed 2–6 months after the last session.
Frequently Asked Questions
What is AestheFill® 200mg?
AestheFill® 200mg is a poly-D,L-lactic acid (PDLLA) collagen biostimulator supplied as a 200mg lyophilized powder. It is reconstituted with sterile water and injected to stimulate the skin's own collagen for gradual volume restoration.
How is AestheFill different from a hyaluronic acid filler?
HA fillers add gel volume immediately; AestheFill is a biostimulator — its PDLLA microspheres prompt new collagen to form over weeks to months, so the result develops gradually and can last up to approximately two years.
What is the difference between PDLLA and PLLA?
AestheFill uses PDLLA (poly-D,L-lactic acid), an amorphous form that reconstitutes faster, needs less water and is associated with a lower complication rate than conventional crystalline PLLA formulations.
How is AestheFill reconstituted?
Add approximately 8 mL of sterile water for injection (SWFI) to the vial and swirl gently until an even suspension forms. Official guidance recommends using sterile water rather than saline.
How many treatment sessions are needed?
Typically around 3 sessions spaced 4–6 weeks apart, using 1–2 vials per session depending on the treatment area and aesthetic goals.
When will results be visible?
Because the effect comes from new collagen formation, results build gradually over weeks to months. Final results are best assessed 2–6 months after the last session.
How long do results last?
Volume results can last up to approximately two years as collagen is gradually stimulated and then slowly resorbed by the body.
Who can administer AestheFill?
Licensed, trained practitioners only. Reconstitution, injection depth and post-treatment massage technique require appropriate training.
Excellent product. Our clinic has been very happy with the results. Definitely reordering.
AestheFill® 200mg — PDLLA Collagen Biostimulator Lyophilized Powder has become our go-to. The 200mg lyophilized powder per vial, reconstituted with ~8ml sterile water gives us confidence in every treatment session.
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